It is obvious that any top 10 road trip article is very subjective and if you asked 10 different people what their top ten was they would all be different.
This Yahoo article, by Becca Begman, has some very interesting trips from California's Big Sur to the Hana Highway, in Hawaii.
The Neon Road has taken several of these trips and can attest to the wonder and awe these roads offer. Big Sur is amazing (although not for the faint of heart driver afraid of shear cliffs and VERY windy roads).
The Red Rock Scenic Byway, in Arizona, is another treat with the amazing red rock formations, with their color changes and geologic formations resembling recognizeable objects.